Abstract #1398

UTILITY OF OXYGEN-ENHANCED LUNG MRI IN LONG TERM POST-LUNG TRANSPLANT PATIENT CARE

Milan Speth^1,2, Till Frederik Kaireit^1,2, Marcel Gutberlet^1,2, Filip Klimeš^1,2, Lea Behrendt^1,2, Andreas Voskrebenzev^1,2, Frank Wacker^1,2, Tobias Welte^2,3, Jens Gottlieb^2,3, and Jens Vogel-Claussen^1,2

¹Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany

Synopsis

Keywords: Lung, Transplantation, Graft loss

Aim of this prospective single-center surveillance study was to assess the ability of oxygen-enhanced MRI to predict future chronic lung allograft dysfunction (CLAD) related transplant loss. Baseline MRI scans were acquired 6-12 months and follow-up MRI 2.5 years after double lung transplantation. T1 mapping was carried out with patients breathing room air and 100% oxygen, Delta T1 maps were calculated. Median, quartile coefficient of dispersion and ventilated volume parameters were correlated with graft loss and compared with same day lung function testing. Oxygen-enhanced MRI predicted future CLAD-related transplant loss 6-12 months post transplantation and, when evaluating %change, at follow-up MRI.

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