Abstract #1399

Double-echo Oxygen Enhanced MRI at 1.5 T correlates with clinical lung function in CF patients

Marta Tibiletti¹, Christopher Short^2,3, Josephine H Naish^1,4, Mary Abkir^2,3, Thomas Semple^2,3,5, Simon Padley^2,3, Jane C. Davies^2,6, and Geoff JM Parker^1,7

¹Bioxydyn Ltd, Manchester, United Kingdom, ²National Heart & Lung Institute, Imperial College London, London, United Kingdom, ³Royal Brompton Hospital, Guy's & St Thomas’ Trust, London, United Kingdom, ⁴MCMR, Manchester University NHS Foundation Trust, Wythenshawe, United Kingdom, ⁵Centre for Paediatric and Child Health, Imperial College London, London, United Kingdom, ⁶Royal Brompton Hospital, , Guy's & St Thomas’ Trust, London, United Kingdom, ⁷Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom

Synopsis

Keywords: Lung, Oxygenation

This study presents the first results from a population with cystic fibrosis (CF) of a novel, easy-to-implement, multi-slice, free breathing OE-MRI acquisition method based on measuring R₂* changes in the lung with varying level of oxygen delivered to the patients.

The oxygen ventilated volume fraction obtained presents a very good correlation with lung clearance index (LCI) obtained by multiple breath N₂ washout. LCI is a marker of overall lung ventilation inhomogeneity, which has been shown to be a sensitive marker of lung disease severity in CF, particularly in the early stage of the disease when spirometry outcomes are normal.

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