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Abstract #1399

Double-echo Oxygen Enhanced MRI at 1.5 T correlates with clinical lung function in CF patients

Marta Tibiletti1, Christopher Short2,3, Josephine H Naish1,4, Mary Abkir2,3, Thomas Semple2,3,5, Simon Padley2,3, Jane C. Davies2,6, and Geoff JM Parker1,7
1Bioxydyn Ltd, Manchester, United Kingdom, 2National Heart & Lung Institute, Imperial College London, London, United Kingdom, 3Royal Brompton Hospital, Guy's & St Thomas’ Trust, London, United Kingdom, 4MCMR, Manchester University NHS Foundation Trust, Wythenshawe, United Kingdom, 5Centre for Paediatric and Child Health, Imperial College London, London, United Kingdom, 6Royal Brompton Hospital, , Guy's & St Thomas’ Trust, London, United Kingdom, 7Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom

Synopsis

Keywords: Lung, Oxygenation

This study presents the first results from a population with cystic fibrosis (CF) of a novel, easy-to-implement, multi-slice, free breathing OE-MRI acquisition method based on measuring R2* changes in the lung with varying level of oxygen delivered to the patients.

The oxygen ventilated volume fraction obtained presents a very good correlation with lung clearance index (LCI) obtained by multiple breath N2 washout. LCI is a marker of overall lung ventilation inhomogeneity, which has been shown to be a sensitive marker of lung disease severity in CF, particularly in the early stage of the disease when spirometry outcomes are normal.

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Keywords