Abstract #1400
Impaired xenon gas transfer observed one year after hospitalisation due to COVID-19 in patients with signs of interstitial lung disease.
Laura Saunders1, Guilhem Collier1, Ho-Fung Chan1, Paul Hughes1, Laurie Smith1, Neil Stewart1, Jonathan Brooke2, James Watson3, James Meiring3, Zoë Gabriel3, Thomas Newman3, Megan Plowright3, Phillip Wade3, James Eaden3, Jody Bray1, Helen Marshall1, David Capener1, Leanne Armstrong1, Jennifer Rodgers1, Martin Brook1, Alberto Biancardi1, Madhwesha Rao1, Graham Norquay1, Oliver Rodgers1, Ryan Munroe1, James Ball1, Neil Stewart1, Gisli Jenkins4, James Grist5, Kher Lik Ng6, Ling-pei Ho5, Fergus Gleeson5, Ian Hall7, Thomas Meersmann7, Galina Pavlovskaya7, Arthur Harrison7, Jonathan Brooke7, Joseph Jacob8, Andrew Swift1, Smitha Rajaram3, Gary Mills1, Lisa Watson3, Paul Collini1, Rod Lawson3, A A Roger Thompson1, and Jim Wild1
1The University of Sheffield, Sheffield, United Kingdom, 2University of Nottingham, Nottingham, United Kingdom, 3Sheffield Teaching Hospitals, Sheffield, United Kingdom, 4Imperial College London, London, United Kingdom, 5University of Oxford, Oxford, United Kingdom, 6Oxford NHS Foundation Trust, Oxford, United Kingdom, 7Nottingham University, Nottingham, United Kingdom, 8University College London, London, United Kingdom
Synopsis
Keywords: Lung, COVID-19Patients with signs of interstitial lung disease at 12 weeks after hospitalisation due to COVID-19 underwent 1H and 129Xe MRI. 129Xe MRI showed impaired xenon gas transfer (RBC:M and RBC:gas) at 24 and 52 weeks after hospital admission, with no longitudinal change between 24 and 52 weeks observed in 129Xe MRI metrics or PFT transfer factor. Xenon MRI metrics correlated significantly with PFT transfer factor at 24 weeks (RBC:M, RBC:gas, LmD) and 52 weeks (RBC:M, RBC:gas, LmD).
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