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Abstract #1401

Retrospective analysis of Hyperpolarized 129Xe MRI Gas Exchange Images in Healthy and Post-COVID-19 Individuals acquired at Three Sites

Peter Niedbalski1, David Mummy2, Haoran Dai2, Aryil Bechtel3, Alexandra Schmidt4, Bradie Frizzell1, Sakib Kabir2, Jonathon Leipsic4,5, Janice Leung4,6, Bastiaan Driehuys2, Loretta Que7, Mario Castro1, Don Sin4,6, and Rachel Eddy4,6
1Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, KS, United States, 2Department of Radiology, Duke University, Durham, NC, United States, 3Department of Medical Physics, Duke University, Durham, NC, United States, 4Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada, 5Department of Radiology, University of British Columbia, Vancouver, BC, Canada, 6Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada, 7Division of Pulmonary Medicine, Duke University, Durham, NC, United States

Synopsis

Keywords: Lung, COVID-19Gas exchange hyperpolarized 129Xe MRI (Xe-MRI) is increasingly being considered as an outcome measure in multi-site clinical trials, but there is limited evidence of between-site comparability. In this study, we analyzed 121 gas exchange Xe-MRI images in healthy and post-acute COVID-19 participants independently acquired at three sites. In healthy volunteers, quantitative Xe-MRI measures are indistinguishable across sites. In post-acute COVID-19, cross-site differences in Xe-MRI measures are evident but appear to be driven by differences in patient population. Moreover, Xe-MRI measures across sites correlate strongly with pulmonary function testing. These results support the feasibility of multi-site trials using gas exchange Xe-MRI.

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