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Abstract #1405

Nominal respiratory features in spontaneous breathing: Towards multiparametric atlases with 3D MR spirometry in healthy volunteers

Nathalie Barrau1, Adrien Duwat1, Killian Sambourg1, Angéline Nemeth1, Antoine Beurnier2, Tanguy Boucneau3, Vincent Lebon1, and Xavier Maître1
1Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay, France, 2Hôpital Bicêtre, APHP, Le Kremlin-Bicêtre, France, 3GE Healthcare, Buc, France

Synopsis

Keywords: Lung, Quantitative Imaging, SpirometryThree-dimensional MR spirometry fosters a double paradigm shift upon standard spirometry: from forced to free breathing and from global to local measurements. The technique makes use of voxel-wise flow-volume loops and original biomechanical markers to characterize the regional lung function. Over a diverse adult population, nominal common features showed up throughout 3D MR spirometry parametric maps in healthy volunteers spontaneously breathing in supine and prone positions. Euclidian barycenter and standard deviation maps of local tidal volumes, spontaneous expiratory peak flows, and anisotropic deformation indices are presented here as the ground for a unique atlas of the lung function.

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Keywords