Abstract #1421

Rapid mesoscale 3D whole-brain MRF in the Next-Generation 7T brain scanner: challenges and advantages

Xiaozhi Cao^1,2, Congyu Liao^1,2, Alexander Beckett^3,4, An Vu^5,6, Samantha Ma⁷, Sophie Schauman^1,2, Siddharth Srinivasan Iyer^1,8, Mahmut Yurt^1,2, Elizabeth Tong¹, Adam Kerr², David A Feinberg^3,4, and Kawin Setsompop^1,2

¹Department of Radiology, Stanford university, Stanford, CA, United States, ²Department of Electrical Engineering, Stanford university, Stanford, CA, United States, ³Helen Wills Neuroscience Institute, University of California, Berkeley, CA, United States, ⁴Advanced MRI Technologies, Sebastopol, CA, United States, ⁵Department of Radiology, University of California, San Francisco, CA, United States, ⁶San Francisco Veteran Affairs Health Care System, San Francisco, CA, United States, ⁷Siemens Medical Solutions USA Inc., Berkeley, CA, United States, ⁸Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States

Synopsis

Keywords: MR Fingerprinting/Synthetic MR, Brain3D MRF with spiral projection trajectory was implemented on the 7T NexGen scanner to take advantage of its SNR benefit and state-of-the-art gradient system. To achieve high-fidelity and high-efficiency multi-parameter mapping at the mesoscale, novel techniques were developed to overcome several technical challenges in performing this acquisition, including spiral residual gradient compensation, trajectory measurement, water-only excitation RF pulse, B₀ correction, B₁⁺ correction and frequency response correction. The proposed technical developments enabled high-quality whole-brain T₁, T₂, and proton density mapping at 1-mm isotropic resolution in 1 minute, and 560mm isotropic resolution in 4-minutes scan time.

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