Abstract #1427

Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate MRI

Peder Eric Zufall Larson¹, Shuyu Tang², Xiaoxi Liu¹, Avantika Sinha¹, Nicholas Dwork³, Sanjay Sivalokanathan⁴, Jing Liu¹, Robert Bok¹, Karen G Ordovas⁵, James Slater¹, Jeremy W Gordon¹, and M. Roselle Abraham¹

¹Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States, ²HeartVista, Palo Alto, CA, United States, ³University of Colorado Anschutz, Aurora, CO, United States, ⁴University of Pennsylvania, Philadelphia, PA, United States, ⁵University of Washington, Seattle, WA, United States

Synopsis

Keywords: Myocardium, Metabolism

Hyperpolarized (HP) ¹³C-pyruvate MRI is a promising new tool for non-invasive quantification of myocardial glycolytic and Krebs cycle metabolism. In this study we evaluated whole-heart imaging and metabolism quantification methods in 7 healthy volunteers under a fasted and fed state. We observed that the ¹³C-pyruvate-to-bicarbonate conversion rate, k_PB, a measure of PDH flux, had the highest, statistically significant correlation with blood glucose levels, with smaller changes in the ¹³C-lactate/pyruvate ratio and ¹³C-pyruvate-to-lactate conversion rate, k_PL. ¹³C-pyruvate and ¹³C-lactate were detected simultaneously in the RV blood pool, immediately after intravenous injection, reflecting LDH activity in blood.

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