Abstract #1428

Diabetic Treatment and Oral Ketone Supplement effect on Cardiac Function and Metabolism in Heart Failure Model by Cardiac and hyperpolarized MRSI

David O. Guarin Bedoya^1,2, Salva Yurista^1,3,4, Jonah P Weigan Witthier¹, Shi Chen^1,3,4, Robert Eder^1,3,4, William Jiang^1,3,4, Feiyang Liu ^1,3,4, Atsushi M. Takahashi⁵, Christopher Nguyen^1,3,4, and Yi-Fen Yen¹

¹Athinoula A. Martinos Center for Biomedical Imaging,Radiology Department, Massachusetts General Hospital, Charlestown, MA, United States, ²Polarize ApS, Frederiksberg, Denmark, ³Corrigan Minehan Heart Center, Division of Cardiology, Massachusetts. General Hospital, Harvard Medical School, Boston, MA, United States, ⁴Cardiovascular Innovation Research Center, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States, ⁵Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Cardiomyopathy, Hyperpolarized MR (Non-Gas), Heart Failure, Contrast Agent, Contrast Mechanisms, MetabolismUsing hyperpolarized [1-¹³C]pyruvate MR spectroscopy imaging and cine MRI, we show that targeting cardiometabolic dysregulation with metabolic treatment, such as ketone ester supplementation and/or sodium–glucose cotransporter 2 inhibitor, was effective in improving cardiac function and ameliorating cardiac remodeling in a preclinical model of HFpEF. These results provide a rationale for the assessment of metabolic interventions for patients with HFpEF.

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