Abstract #1433

Free-breathing simultaneous myocardial T2 and T1ρ mapping for non-contrast assessment of uremic cardiomyopathy

Qinfang Miao^1,2, Zhenfeng Lv^1,2, Sha Hua³, Zhongqi Zhang⁴, Jian Xu⁴, Peng Hu^1,2, and Haikun Qi^1,2

¹School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, ²Shanghai Clinical Research and Trial Center, Shanghai, China, ³Department of Cardiovascular Medicine, Ruijin Hospital Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴UIH America, Inc., Houston, TX, United States

Synopsis

Keywords: Myocardium, Cardiomyopathy

Uremic cardiomyopathy is the adverse cardiac remodeling that commonly occurs in patients with chronic kidney disease. Previous studies have indicated increased intramyocardial fluid and myocardial fibrosis in uremic patients, which makes native myocardial T2 and T1ρ mapping ideal imaging biomarkers to characterize these changes. Therefore, we propose a free-breathing simultaneous T2 and T1ρ mapping technique to provide co-registered T2 and T1ρ maps. The proposed technique was firstly evaluated in phantoms and ten healthy subjects, which achieved similar performance to the conventional separate T2 and T1ρ mapping methods. The preliminary validation in four hemodialysis patients showed promising results.

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