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Abstract #1438

Alteration of sacroiliac fatty acids composition in axial spondyloarthritis: analysis using 3.0 T chemical shift-encoded MRI

Min Chen1,2, Chuanli Cheng1, Chao Zou1, and Guanxun Cheng2
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Radiology Department, Peking University Shenzhen Hospital, Shenzhen, China

Synopsis

Keywords: Joints, Quantitative Imaging, axial spondyloarthritis; bone marrow; fatty acidsChanges of bone marrow fatty acids (FAs) composition have been detected in several inflammatory and metabolic diseases by MRI. However, the alteration of sacroiliac FAs composition in axial spondyloarthritis (axSpA) remains unknown. We observed changes of bone marrow FAs composition of the sacroiliac joint in patients with axSpA compared to controls using chemical shift-encoded MRI (CSE-MRI). The changes differed between areas with fat metaplasia and areas without fat metaplasia in axSpA. Our results indicated bone marrow FAs including saturated FA, mono-unsaturated FA and poly-unsaturated FA may play different roles in the pathogenesis of axSpA.

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