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Abstract #1449

Intravoxel Incoherent Motion Diffusion-weighted MR Imaging and IDEAL-IQ for Assessment of Treatment Response in Multiple Myeloma

Yanhua Tang1, Li Wang2, and Yichen Ma3
1Radiology, Beijing Chao-Yang Hospital, Capital Medical Universit, Beijing, China, 2Beijing Chao-Yang Hospital, Capital Medical Universit, Beijing, China, 3Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

Synopsis

Keywords: Bone, Diffusion/other diffusion imaging techniques, intravoxel incoherent motion, diffusion-weighted imaging, iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence (IDEAL-IQ), multiple myeloma, treatment responseThis study explored the feasibility of IVIM DWI and IDEAL-IQ parameters in evaluating the treatment response of patients with multiple myeloma (MM) who received systemic treatment within 6 months. The results showed that within 6 months after treatment, the changes of D and f values of IVIM DWI in deep-responders before and after treatment were significantly different from those in non-deep responders.This indicates that the changes of D and f values of IVIM DWI may be helpful to evaluate the short-term (within 6 months) therapeutic response of myeloma, while the evaluation of IDEAL-IQ on short-term therapeutic response needs further study.

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