Abstract #1450

The Effect of Long-term Exercise Training on Metabolic Responses in Obese Zucker Fatty Diabetic Rats using Phosphorous-31 MRS

Kihwan Kim¹, Yuran Zhu¹, Raodatullah Abodunrin¹, Sonia Kumar ¹, Jessica Meng¹, Luchen Yu¹, Allison McKenzie ¹, and Xin Yu^1,2

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States

Synopsis

Keywords: Muscle, DiabetesIn this study, metabolic responses to 10-week treadmill exercise on obese Zucker rats were examined using ³¹P magnetic resonance spectroscopy. Exercise resulted in improvement in glucose tolerance and aerobic capacity (VO_2max) while retaining mitochondrial oxidative capacity (MOC) and creatine kinase (CK) activity. Sedentary rats, however, showed poor glucose tolerance and reduced VO_2max, which were also marked by significant changes in their MOC and CK activity.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.