Abstract #1452

Do adult patients with moyamoya disease have glymphatic system dysfunction? - evaluation using diffusion along perivascular space

Shoko Hara^1,2,3, Junko Kikuta², Kaito Takabayashi², Koji Kamagata², Shihori Hayashi^1,4, Motoki Inaji^1,3, Yoji Tanaka¹, Masaaki Hori², Kenji Ishii⁴, Tadashi Nariai^1,4, Toshiaki Taoka⁵, Shinji Naganawa⁶, Shigeki Aoki², and Takeoshi Maehara¹

¹Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan, ²Radiology, Juntendo University, Tokyo, Japan, ³Research Team of Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, ⁴Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, ⁵Innovative Biomedical Visualization, Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁶Radiology, Nagoya University, Nagoya, Japan

Synopsis

Keywords: Neurofluids, Diffusion/other diffusion imaging techniques, glymphatic systemWe aimed to evaluate the glymphatic system of adult moyamoya disease (MMD) by measuring diffusion along the perivascular space (DTI-ALPS index). We evaluated 46 patients using diffusion MRI, perfusion parameters of ¹⁵O-gas PET, and cognitive tests, and 34 age-sex-matched normal controls. Compared to normal controls, patients with MMD showed significantly lower DTI-ALPS index. DTI-ALPS index in MMD revealed the correlation between perfusion and freewater parameters, and executive dysfunction, and suggested that dysfunction of the glymphatic system may exist, correlate with the degree of hemodynamic disturbance, lead to increased parenchymal free water, and relate to cognitive dysfunction in adult MMD.

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