Keywords: Neurofluids, Neurofluids
We designed a non-invasive multimodal MRI approach to evaluate the relationship between cardiac pulsation and perivascular cerebrospinal fluid (pCSF) dynamics in humans. We utilized cardiac-aligned resting-state functional MRI and dynamic diffusion-weighted imaging to describe cerebral vascular events and pCSF motion, respectively. This approach revealed that changes in cerebral blood volume preceded an increase in pCSF motion, demonstrating the cardiac cycle’s effect on pCSF dynamics. Our results parallel preclinical two-photon imaging findings of perivascular CSF dynamics in mice. Our in-vivo assessment of cardiac pulsations influencing pCSF motion provides a non-invasive look into a crucial part of the human brain’s glymphatic system.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords