Abstract #1454

TOTAL WHITE MATTER PERIVASCULAR SPACE VOLUME: AN EARLY MARKER FOR DUTCH-TYPE CEREBRAL AMYLOID ANGIOPATHY

Manon Roxanne Schipper¹, Arie-Tjerk Razoux-Schultz², Thijs W. van Harten¹, Jeroen van der Grond¹, Mark van Buchem¹, Steven M. Greenberg³, Marieke J.H. Wermer⁴, Matthias J.P. van Osch¹, Marianne A.A. van Walderveen¹, and Sanneke van Rooden¹

¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Neurology, Mass General Research Institute, Boston, MA, United States, ⁴Neurology, Leiden University Medical Center, Leiden, Netherlands

Synopsis

Keywords: Neurofluids, Neurofluids, Perivascular spacesIn this study we semi-automatically quantified MRI-visible perivascular space volume in the white matter (WM-PVS) and compared these volumes between (pre-)symptomatic Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA) and matched controls. Main findings show that the WM-PVS volume was significantly higher in symptomatic D-CAA (median=19.9mL) compared with both presymptomatic D-CAA (median=3.5mL; U=19, p=.01) and matched controls (median=4.9mL; U=1, p<.001). Presymptomatic D-CAA carriers had a higher WM-PVS volume than the matched controls (median=2.3mL; U=27, p=.02). This indicates that WM-PVS volume, in contrast to the PVS-CSO visual rating scales, may be an early marker for D-CAA.

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