Abstract #1455

Higher blood flow velocity pulsatility relates to increased interstitial fluid diffusivity - a potential proxy of high perivascular fluid flow

Merel M. van der Thiel^1,2,3, Marieke van den Kerkhof^1,2, Alida A. Postma^1,2, Walter H. Backes^1,2,4, and Jacobus F.A. Jansen^1,2,5

¹Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ²School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, ³Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, Netherlands, ⁴Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands, ⁵Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Synopsis

Keywords: Neurofluids, Aging, Diffusion, pulsatility, waste clearanceImpaired cerebral waste clearance occurs in healthy ageing and various neurodegenerative diseases and is theorized to be due to compromised arterial pulsatility. Profiting from high-resolution 7 Tesla MRI, the current study investigated the association between pulsatility characteristics of a small artery in the basal ganglia (BG) with interstitial fluid (ISF) characteristics of the BG - as derived with intravoxel incoherent motion. This study found that an increased small vessel velocity pulsatility was related to higher ISF-diffusivity in the BG of an elderly sample. This increased ISF-diffusivity might represent increased perivascular fluid diffusivity, influencing the waste fluid transport out of these spaces.

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