Abstract #1457

Blockage of CSF Outflow via Nasal Lymphatic Pathway in Rats after Deep Cervical Lymph Node Ligation Observed Using Intrathecal Gd-based MR Imaging

Naoya Kinota^1,2, Hiroyuki Kameda^3,4, Kazuyuki Minowa³, and Kohsuke Kudo^1,5

¹Department of Diagnostic Imaging, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Department of Dental Radiology, Hokkaido University Hospital, Sapporo, Japan, ³Department of Radiology, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan, ⁴Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, ⁵Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan

Synopsis

Keywords: Neurofluids, Neurofluids, Glymphatic SystemPrevious reports showed that deep cervical lymph nodes (DCLNs) receive cerebrospinal fluid (CSF) outflow. DCLN ligation resulted in intracranial accumulation of waste proteins due to impaired CSF outflow; however, changes in extracranial outflow after DCLN ligation have not been directly observed. We examined extracranial CSF outflow in rats after DCLN ligation by using intrathecal gadolinium (Gd)-based dynamic contrast-enhanced MRI. DCLN ligation blocked CSF- tracer outflow into the nasal cavity. A weak trend towards CSF-tracer retention in the ventral cistern was also observed. These results suggest that DCLN ligation affects CSF outflow in rodents.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.