Abstract #1458

CSF pseudo-diffusion spatial statistics for whole-brain voxel-wise analysis of CSF flow

Arash Nazeri¹, Taher Dehkharghanian², Pamela J. LaMontagne¹, Tammie L.S. Benzinger¹, and Aristeidis Sotiras^1,3

¹Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, ²Faculty of Health Science, McMaster University, Hamilton, ON, Canada, ³Institute for Informatics, Washington University in St. Louis, St. Louis, MO, United States

Synopsis

Keywords: Neurofluids, Diffusion/other diffusion imaging techniques, cerebrospinal fluidAlterations in CSF flow patterns have been implicated in various brain disorders. At low b-values, diffusion-weighted imaging is sensitive to pseudorandom CSF flow. Here, we present CSF pseudo-diffusion spatial statistics (CΨSS), a whole-brain multi-subject voxel-wise analysis framework that exploits low-b-value diffusion-weighted imaging to study regional patterns of CSF flow. Using this technique, we show how brain atrophy and ventricular volumes affect regional CSF pseudorandom flow. In conclusion, CΨSS is a simple and effective approach for characterizing determinants of regional CSF pseudorandom flow.

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