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Abstract #1459

Physical exercise activates intrinsic CSF outflow metrics in healthy humans

Mitsue Miyazaki1, Vadim Malis1, Asako Yamamoto2, Jirach Kungsamutr3, Marin McDonald1, Linda McEvoy1, and Won Bae1,4
1Radiology, University of California, San Diego, La Jolla, CA, United States, 2Radiology, Teikyo University, Tokyo, Japan, 3Bioengineer, University of California, San Diego, La Jolla, CA, United States, 4VA San Diego Healthcare System, San Diego, CA, United States

Synopsis

Keywords: Neurofluids, Neurofluids, CSF, glymphatic egress pathways, active and sedentaryPossible two intrinsic CSF egress pathways of dura mater and the lower parasagittal dura (PSD) are observed using non-contrast spin-labeling MRI. Intrinsic CSF outflow metrics increase in the adults with an active lifestyle than adults with sedentary lifestyle. However, after 3 weeks of increased physical activity, the sedentary group showed improved CSF outflow metrics. This improvement was notable at the lower PSD, where outflow metrics were highest among the active group. These quantitative CSF results indicate a new pathway of CSF flow from the lower PSD to the superior sagittal sinus that is most evident in physically active individuals.

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Keywords