Abstract #1460

Cerebrospinal fluid pathways are perturbed in aging and prodromal Alzheimer’s disease

Tekla Maria Kylkilahti^1,2, Max Wictor^1,2, David Berron³, Johannes Töger⁴, Karin Markenroth Bloch⁵, Niklas Mattson-Carlgren³, Oskar Hansson^3,6, and Iben Lundgaard^1,2

¹Experimental medical science, Lund University, Lund, Sweden, ²Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden, ³Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden, ⁴Skåne University Hospital, Department of Clinical Sciences Lund, Diagnostic Radiology, Lund University, Lund, Sweden, ⁵Lund University Bioimaging Center, Lund University, Lund, Sweden, ⁶Neuropsychiatric Clinic, Malmö University Hospital, Malmö, Sweden

Synopsis

Keywords: Neurofluids, Velocity & Flow

Cerebrospinal fluid (CSF) circulation through the parenchyma by the glymphatic system has been suggested to play a role in the clearance of metabolic waste from the brain, including Amyloid β. In this 7T MRI study of CSF flow in the cerebral aqueduct, we find that ageing, cognitive status and amyloid status influence CSF dynamics and morphology of the aqueduct. These changes appear to precede major cognitive changes in Alzheimer’s disease. Disruption of flow dynamics and anatomy of CSF flow pathways may reflect dysfunctional CSF circulation in downstream compartments of the glymphatic system, and contribute to amyloid accumulation in the brain.

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