Abstract #1464

The impact of infusion rate on Gd-DTPA transport in the glymphatic system in mouse brain

Yuran Zhu¹, Guanhua Wang², Kihwan Kim¹, Chris A. Flask^1,3,4, and Xin Yu^1,3,5

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ³Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States, ⁵Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

Synopsis

Keywords: Neurofluids, Contrast Agent, Glymphatic systemThis study evaluated the impact of infusion rate on tracer transport in mouse glymphatic system. Gd-DTPA was administered via cisterna magna at a rate either comparable to the CSF production rate in mouse brain (0.33 μL/min) or three-fold higher (1 μL/min). The kinetics and distribution of Gd-DTPA were assessed by DCE-MRI for 2 hours. Our results show a significantly increased transport along the dorsal brain regions and penetration into the deep brain regions at a slow infusion rate, suggesting that the infusion rate may alter the pressure gradient and affect tracer transport and distribution in the brain.

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