Abstract #1470

Delta-Radiomic Based on Dynamic Contrast Enhanced MRI Predicts axillary Response after neoadjuvant chemotherapy in breast cancer patients

Shasha Liu¹, Siyao DU¹, Si Gao¹, Lizhi Xie², Yuee Teng³, Feng Jin⁴, and Lina Zhang¹

¹Department of Radiology, The First Hospital of China Medical University, shenyang, China, ²MR Research, GE Healthcare, Beijing, China, ³Departments of Medical Oncology and Thoracic Surgery, The First Hospital of China Medical University, shenyang, China, ⁴Department of Breast Surgery, The First Hospital of China Medical University, shenyang, China

Synopsis

Keywords: Breast, Radiomics, DCE-MRIThis prospective study with multiple follow-up time points investigated the early predictive value of the delta-radiomic model of axillary lymph node (ALN) using dynamic contrast-enhanced (DCE) MRI for axillary pathological complete response (pCR) in breast cancer patients after neoadjuvant chemotherapy (NAC). The results indicated that the delta-radiomic model based on early changes of ALN features performed better among all radiomic models. Moreover, when combined with clinical features, the combined model achieved the best diagnostic performance of any model we tested. The delta-radiomic + clinical model may be a promising method for ALN pCR prediction in the initial phase of NAC.

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