Abstract #1487

Assessment of IVIM-DKI for characterization of benign and malignant lymph nodes in lymphoma

Archana Vadiraj Malagi^1,2, Devasenathipathy Kandasamy³, Deepam Pushpam⁴, Kedar Khare⁵, Raju Sharma³, Rakesh Kumar⁶, Sameer Bakhshi⁴, and Amit Mehndiratta^1,7

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi (IIT Delhi), New Delhi, India, ²Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ³Department of Radiodiagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, ⁴Department of Medical Oncology, Dr. B.R. Ambedkar Institute-Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences Delhi, New Delhi, India, ⁵Department of Physics, Indian Institute of Technology Delhi (IIT Delhi), New Delhi, India, ⁶Department of Nuclear Medicine, All India Institute of Medical Sciences Delhi, New Delhi, India, ⁷Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India

Synopsis

Keywords: Cancer, Diffusion/other diffusion imaging techniquesIntravoxel Incoherent motion-diffusion kurtosis imaging (IVIM-DKI) was used for evaluation and characterization of malignant lymph nodes in lymphoma. A total of twenty-one (n=21) patients diagnosed with biopsy proven Hodgkin lymphoma(HL: n=13) or non-Hodgkin lymphoma(NHL: n=8) were prospectively evaluated. IVIM-DKI parameters were estimated using standard IVIM-DKI model (standard model) and IVIM-DKI model with total variation(TV) penalty function method(IDTV model). Perfusion fraction (f) and kurtosis (k) estimated using IDTV model, and apparent diffusion coefficient(ADC) were significantly(p<0.05) lower in malignant lymph nodes than benign lymph nodes. f and k showed high AUC of 0.88 and 0.83, respectively for malignant vs. benign lymph nodes.

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