Keywords: Cancer, Deuterium, deuterium MR imagingDMI emerged as a promising alternative in cancer metabolic imaging. We D2O-induced 2H-labeling followed by DMI to study deuterium kinetics and track tumor response to treatment at 1.5T. We succeeded to use dMRI to monitor 2H kinetics in tissues of a pancreatic carcinoma model. Higher 2H build-up was observed in tumor. Treated mice showed a significant decrease in 2H in tumor during 7 days of treatment and before anatomical changes were detectable. Tumor homogenates of treated mice also showed a significant reduction in 13C lactate production. DMI of tumors is a potential imaging method for assessment of early treatment responses
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