Abstract #1490

Quantification of Acute and Chronic Fibrosis in Gynecologic and Prostate Cancer over the course of Radiotherapy

Khadija Sheikh¹, Akila N Viswanathan¹, Daniel Y Song¹, Junichi Tokuda², Junghoon Lee¹, Michael Jerosch-Herold², Mindy K Graham¹, Ravi Seethamraju³, Thomas Benkert⁴, Himanshu Bhat⁵, Bruce L Daniels⁶, and Ehud J Schmidt^1,7

¹Radiation Oncology and Molecular Sciences, Johns Hopkins University School of Medicine, Washington, DC, United States, ²Radiology, Brigham and Women’s Hospital, Boston, MA, United States, ³Siemens Medical Solutions, Boston, MA, United States, ⁴MR Applications Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ⁵Siemens Healthineers, Boston, MA, United States, ⁶Radiology, Stanford University, Stanford, CA, United States, ⁷Medicine (Cardiology), Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Pelvis, Radiotherapy, acute and chronic fibrosisWe developed means to quantify the volume and voxel-wise fraction of acute (F_A) and chronic fibrosis (F_C) present during and following radiation therapy (RT), using non-contrast and contrast enhanced stack-of-spirals IR-UTE scans. Imaging was performed in gynecologic and prostate cancer patients at multiple time points in relation to RT (pre-RT, on-RT, post-RT, and post-3 months RT). This study provides mm-resolution quantitative information on fibrosis changes during the course of RT based on MRI. Increases in F_A, followed by subsequent-time F_C increases were observed in both prostate and gynecologic cancer patients.

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