Abstract #1491

Early monitoring of radiation treatment based on tumor redox status using in vivo dynamic nuclear polarization MRI

Fuminori Hyodo¹, Norikazu Koyasu¹, Ryota Iwasaki¹, Hinako Eto², Abdelazim Elsayed Elhelaly¹, Hiroyuki Tomita¹, Takashi Elsayed Mori¹, Masaharu Murata², Yoshifumi Noda¹, Hiroki Kato¹, and Masayuki Matsuo¹

¹Gifu University, Gifu, Japan, ²Kyushu University, Fukuoka, Japan

Synopsis

Keywords: Cancer, Hyperpolarized MR (Non-Gas), redox, DNP MRI, radiationIn vivo dynamic nuclear polarization-MRI (DNP-MRI, also called OMRI, PEDRI) using carbamoyl-PROXYL(CmP) as a redox sensitive DNP probe enables the accurate monitoring of the tissue redox status. We found that the redox status decreases 1 day after radiation treatment, and the decay of redox status occurs before any micro- or macroscopic changes in tumor morphology and pyruvate metabolism based on the Warburg effect. This decay of redox status can also be associated with the decreased production of intratumor reducing redox molecules such as GSH and AsA.

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