Keywords: Cancer, Diffusion/other diffusion imaging techniquesSystematic clinical validation of noise-corrected, exponentially-weighted, diffusion-weighted MRI (niceDWI) is performed in metastatic melanoma including soft tissue disease. Previous assessments of niceDWI demonstrated improvement in the in-plane bias field. No clinical advantage is found over clinical DWI: the signal-to-noise ratio was assessed as significantly worse in niceDWI both quantitatively and by an experienced reader; there was no difference demonstrated in the contrast-to-noise ratio (CNR) of bone or nodal lesions; when soft tissue disease is included CNR is significantly worse on niceDWI. It is recommended that future evaluations of niceDWI assess the maximum intensity projection for use as a survey tool.
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