Abstract #1504

Discriminating Locally advanced and Metastatic Lung Cancer using Restriction Spectrum Imaging and Intravoxel Incoherent Motion Model

Zhongyan Xiong¹, Yu Luo², Yang Yang³, Meiyun Wang², Xin Liu^4,5, Hairong Zheng¹, and Chao Zou^4,5

¹Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Department of Medical Imaging, Henan Provincial People’s Hospital & Zhengzhou University People’s Hospital, Zhengzhou, China, ³Central Research Institute, United Imaging Healthcare, Shanghai, China, ⁴Paul C. Lauterbur Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ⁵Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China

Synopsis

Keywords: Lung, Diffusion/other diffusion imaging techniquesA novel diffusion weighted imaging model called restriction spectrum imaging (RSI) captures the distinct diffusion behavior of tumors. The restricted diffusion correlates to tumor cellularity, a potential indicator of cancer aggressiveness. To assess its capability of characterizing lung cancer metastasis, we applied a three-compartment RSI model and intravoxel incoherent motion model to DWI images of locally advanced and metastatic lung cancer patients with the diagnosis of biopsy. The RSI model demonstrated its ability to discriminate the lung cancer of locally advanced (III) and metastatic (IV) stage, and the results outperforms the traditional IVIM model.

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