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Abstract #1517

Longitudinal study investigation of CMR measures and cardiac allograft vasculopathy over time

Sandra Quinn1, Chantelle Sanchez1, Ozden Kilinc1, Kai Lin1, Kambiz Ghafourian2, Daniel C Lee2, Esther E Vorovich2, Clyde W Yancy2, Vera H Rigolin2, Jon W Lomasney3, Bradley D Allen1, James C Carr1, and Michael Markl1
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 2Department of Medicine, Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 3Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States

Synopsis

Keywords: Myocardium, Transplantation, cardiac allograft vasculopathyCAV is a leading cause of mortality in HTx patients. Diagnosis and grading of CAV is dependent on repeated ICA which carries risk of major complications. CMR has the potential to be useful in CAV surveillance without the risk of ICA. This study has demonstrated that in a group of long-term heart transplant patients with evidence of CAV progression who undergo serial CMR and ICA within a close timeframe, 2D global peak strain parameters and 2D systolic strain rate correlates with CAV severity grade. FTS may therefore prove useful for surveillance of patients for CAV.

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Keywords