Abstract #1523

Pathological changes of the coronary microvascular dysfunction pig models based on diffuse tensor imaging (DTI)

Zilong Ren¹, Didi Wen², Jianxiu Lian³, and Minwen Zheng⁴

¹Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China, ²Department of Radiology, Xijing Hospital, Forth Military Medical University, Xi'an, China, ³Philips Healthcare China, Xi'an, China, ⁴Xijing Hospital, Fourth Military Medical University, Xi'an, China

Synopsis

Keywords: Heart, AnimalsTo investigate whether diffuse tensor imaging (DTI) can be used as a predictor for coronary microvascular dysfunction (CMD). Pig models with CMD had higher mean diffusivity (MD), lower FA, and lower E2A compared with normal pigs (mean MDnormal = 1.50 ± 0.02, mean MDCMD = 1.65 ± 0.02, P = 0.001; mean FAnormal = 0.35 ± 0.01, mean FACMD = 0.27 ± 0.01, P < 0.001; mean E2Anormal = 53.33 ± 0.88, mean E2ACMD = 46.57 ± 1, P = 0.004). Cardiac DTI technology could add benefits of offering microstructure change and cardiac remodeling parameters for CMD pig models.

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