Abstract #1527

Characterization of white matter microstructural abnormalities in cerebral small vessel disease with cerebral microbleeds

Chaofan Sui¹, Hongwei Wen², Shengpei Wang³, Mengmeng Feng⁴, Haotian Xin⁴, Yian Gao¹, Jing Li⁵, Lingfei Guo¹, and Changhu Liang¹

¹Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ²Key Laboratory of Cognition and Personality (Ministry of Education); School of Psychology, Southwest University, Chongqing, China, ³Research Center for Brain-inspired Intelligence Institute of Automation, Chinese Academy of Sciences, Beijing, China, ⁴Department of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, China, ⁵Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Bijing, China

Synopsis

Keywords: Neurodegeneration, White MatterTo characterize white matter (WM) microstructural abnormalities in patients with cerebral small vessel disease (CSVD) coexisting with cerebral microbleeds (CMBs) and to further investigate the exact mechanism by which CMBs influence cognitive decline in patients with CSVD at the group and individual levels. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) images from 49 CSVD patients with CMBs (CSVD-c), 114 CSVD patients without CMBs (CSVD-n), and 83 controls were analyzed using DTI-derived tract-based spatial statistics to detect WM diffusion changes among groups.

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