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Abstract #1529

Mapping neuromelanin loss in clinically uncertain parkinsonism differentiates neurodegenerative from non-neurodegenerative

Yue Xing1,2,3, Stefan Pszczolkowski1, Saadnah Naidu1,2,3, Tayyib Hayat1,2,3,4, Jonathan Evans4, Christophe R Tench1,3, Schwarz T Stefan1,2,5, and Dorothee P Auer1,2,3
1Mental Health and Clinical Neuroscience Unit, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, 4Nottingham University Hospitals, Nottingham, United Kingdom, 5Department of Radiology, Cardiff and Vale University, Cardiff, United Kingdom

Synopsis

Keywords: Neurodegeneration, Neurodegeneration, clinical uncertain Parkinsonism, NM-MRIBrain dopamine transporter SPECT imaging is routinely used to assess striatal dopaminergic deficit in the differentiation of essential tremor from degenerative parkinsonism in clinically uncertain parkinsonism (CUP). Neuromelanin (NM)-MRI detects nigral depigmentation with good diagnostic accuracy in confirmed Parkinson’s Disease; but its diagnostic value in CUP is unclear. Using voxel-based analysis following optimised automatic registration, we investigated the topography of NM loss in CUP, and show that voxels that best discriminate between non-neurodegenerative and neurodegenerative CUP are co-located in the dorsolateral substantia nigra.

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