Abstract #1530
Vascular contribution to the preclinical stages of Alzheimer’s disease: Insights from the EPAD cohort
Luigi Lorenzini1, Alessio Maranzano2, Lyduine E Collij1, Carole H Sudre3, Robin Wolz4, Sven Haller5, Kaj Blennow6, Giovanni B Frisoni7, Pierre Payoux8, Pablo Lage-Martinez9, Michael Ewers 10, Gael Chatelat11, Adam Waldman 12, Joanna Wardlaw 12, Nick Fox 13, Craig Ritchie 14, Philip Scheltens 15, Pieter Jelle Visser 15, Alle Meije Wink 1, Henk JMM Mutsaerts 1, Juan Domingo Gispert 16, Silvia Ingala 1, and Frederik Barkhof1
1Amsterdam UMC, Amsterdam, Netherlands, 2Department of Neurology-Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS - Department of Pathophysiology and Transplantation, “Dino Ferrari” Center, Università degli Studi di Milano, Milan, Italy, Milan, Italy, 3MRC Unit for Lifelong Health and Ageing at UCL, London, UK, London, United Kingdom, 4IXICO, London, United Kingdom, 5CIRD Centre d’Imagerie Rive Droite, Geneva, Switzerland, Geneva, Switzerland, 6Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Sweden, Gothenburg, Sweden, 7University Hospitals and University of Geneva, Geneva, Switzerland, 8Department of Nuclear Medicine, Toulouse CHU, Purpan University Hospital, Toulouse, France, 9Centro de Investigación y Terapias Avanzadas, Neurología, CITA‐Alzheimer Foundation, San Sebastian, Spain, 10German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Strasse 17, Munich, Germany, 11Université de Normandie, Unicaen, Inserm, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood-and-Brain @ Caen-Normandie, Cyceron, 14000, Caen, France, 12Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, 13Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom, 14Centre for Dementia Prevention, The University of Edinburgh, Edinburgh, Scotland, 15Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands, 16Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain
Synopsis
Keywords: Neurodegeneration, Alzheimer's Disease, Cerebrovascular, radiological
Evidence suggests that cardiovascular risk factors and cerebrovascular disease contribute to the Alzheimer’s disease (AD) pathophysiology. It is still unclear to what extent vascular and amyloid pathology have a synergistic or independent influence in preclinical AD stages. We used structural equation models in a cohort of cognitively unimpaired individuals to investigate if cerebrovascular pathology mediates the relationship between cardiovascular risk factors and CSF Aβ1-42, and show that cerebrovascular pathology accelerates downstream AD markers (p-Tau181 and hippocampal volume) by increasing amyloid pathology.
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