Abstract #1533

Examining the consistency of brain MRI structural and functional readouts using repeat imaging from the longitudinal UK Biobank MRI Study.

Guocheng Jiang¹, Jennifer S Rabin^2,3,4,5, Walter Swardfager^2,6, Hugo Cogo-Moreira⁷, and Bradley J MacIntosh^1,8

¹Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada, ³Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Department of Medicine Division of Neurology, University of Toronto, Canada, Toronto, ON, Canada, ⁵Graduate Department of Rehabilitation Science, University of Toronto, Toronto, ON, Canada, ⁶Department of pharmacology and toxicology, University of Toronto, Toronto, ON, Canada, ⁷Department of Education, ICT and Learning, Østfold University College, Halden, Norway, ⁸Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway

Synopsis

Keywords: Neurodegeneration, fMRI, Structural MRIWe aim to study structural and functional changes over time with a focus on the thalamus and hippocampus regions of interest. Longitudinal analysis was performed in N=274 UK Biobank participants. We find strong correlations between the baseline and follow-up MRI readouts. Namely, it is possible to predict thalamus and hippocampus volume changes across a mean of 2.25 years using baseline volume and resting state functional activation estimates. This work helps characterizing the longitudinal consistencies within both hippocampal and thalamic MR readouts and helps setting up prediction models as the next step.

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