Keywords: Neurodegeneration, Diffusion Tensor ImagingWomen undergoing hysterectomy with oophorectomy have an increased risk of Alzheimer’s disease. However, postoperative neuroimaging data on pathogenic processes in the brain are limited. This study was aimed to investigate the potential effect of ovariohysterectomy on brain integrity in the rat model using diffusion tensor imaging technique. Compared to the control group, the ovariohysterectomy group showed significantly lower fractional anisotropy in the corpus callosum, bilateral striatum, and bilateral cortex, suggesting neuronal injury in ovariohysterectomized rats. Therefore, neuroimaging should be performed to monitor brain alterations in women after hysterectomy with bilateral oophorectomy in clinical settings.
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