Abstract #1538

Neuromelanin-MRI Assessment in Dementia with Lewy Bodies

Rotem Iris Orad^1,2,3, Moran Artzi^1,2,4, Noa Bregman^2,3, Anat Mirelman^2,4,5, Avner Thaler^2,4,5, Amgad Droby^2,4,5, Orly Goldstein⁶, Mali Gana-Weisz⁶, Netanell Avisdris¹, Avi Orr-Urterger^2,4,6, Nir Giladi^2,3,4,5,6,7, Tamara Shiner^2,3,4,7, and Dafna Ben Bashat^1,2,4

¹Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, ³Center for Cognitive Neurology Unit, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁴Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, ⁵Laboratory of Early Markers of Neurodegeneration, Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁶The Genomic Research Laboratory for Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁷Movement Disorders Unit, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Synopsis

Keywords: Neurodegeneration, Genetics, Dementia with Lewy Bodies

Reduced neuromelanin-MRI signal and volume are known in Parkinson's disease (PD). However, changes in neuromelanin-MRI with Dementia with Lewy bodies (DLB) and whether there are genotype-related differences are unknown. In this study, we showed reduced neuromelanin signal and volume in patients with DLB compared to healthy controls. Yet, no differences were detected between genotype groups: DLB with and without GBA mutation. Results may suggest the same pathomechanism underlying DLB, PD and other neurodegenerative parkinsonian syndromes, with depletion of neuromelanin within the substantia nigra.

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