Abstract #1539

Reduction of GABA in the visual cortex of glaucoma patients is linked to decreased neural specificity.

Ji Won Bang¹, Carlos Parra¹, Kevin Yu¹, Gadi Wollstein^1,2,3, Joel S Schuman^1,2,3,4, and Kevin C Chan^1,2,3,4,5

¹Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States, ²Center for Neural Science, College of Arts and Science, New York University, New York, NY, United States, ³Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY, United States, ⁴Neuroscience Institute, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States, ⁵Department of Radiology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States

Synopsis

Keywords: Neurodegeneration, BrainGlaucoma is an age-related neurodegenerative disease of the visual system. Although increasing number of studies indicated its widespread involvements of the eye and the brain, very little is known about the underlying metabolic mechanisms. Thus, here we investigated the GABAergic and glutamatergic systems in the visual cortex of glaucoma patients, as well as neural specificity. Our study demonstrated that glaucoma is accompanied by the reduction of GABA and glutamate in the visual cortex. Further, the reduction of GABA but not glutamate predicted neural specificity. This suggests that GABA loss in the visual cortex degrades the neural specificity in glaucoma.

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