Meeting Banner
Abstract #1540

Evidence of association between lower cerebral white matter myelin content and rapid cognitive decline in cognitively unimpaired individuals

Zhaoyuan Gong1, Murat Bilgel2, Matthew Kiely1, Curtis Triebswetter1, Luigi Ferrucci3, Susan M. Resnick2, Richard G. Spencer1, and Mustapha Bouhrara1
1Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, United States, 2Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, United States, 3Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, United States

Synopsis

Keywords: Neurodegeneration, Aging, MyelinMyelin plays an essential role in the normal functioning of the central nervous system. However, how myelination influences longitudinal changes in cognitive performance, especially in cognitively normal (CN) individuals, remains unclear. Using a linear mixed-effects regression analysis, we examined the association between myelin content and changes in cognitive domain scores obtained over several years prior to the time of the MRI scan. We demonstrated strong and statistically significant relationships between myelin content and the rates of change in cognitive performance in several white matter regions. These findings highlight the importance of white matter, specifically myelin integrity, in cognitive functioning.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords