Meeting Banner
Abstract #1541

Altered neurochemical profiles and volume loss in the cerebellum and brainstem as biomarkers in spinocerebellar ataxia type 1

Kirsten Kapteijns1, Teije van Prooije1, Jack JA van Asten2, Marcel Verbeek1, Bart van de Warrenburg1, and Tom WJ Scheenen2
1Neurology, Radboudumc, Nijmegen, Netherlands, 2Medical Imaging, Radboudumc, Nijmegen, Netherlands

Synopsis

Keywords: Neurodegeneration, Spectroscopy, Single Voxel Spectroscopy

Spinocerebellar ataxia type 1 is a rare, progressive movement disorder primarily affecting the cerebellum and closely connected brain regions. We assessed the dynamics of MR biomarkers and their utility as progression and/or predictive biomarkers in SCA1. SCA1 patients showed an altered neurochemical profile when compared to controls. Additionally, we measured a lower volume of affected regions in patients, clearly distinguishing them from controls. Altered volume correlated strongest with clinical scores, confirming the potential to use MR-markers to monitor SCA1 progression. Furthermore, MRS markers correlated with consequent change in volumetric measures, showing preliminary evidence for their predictive value in SCA1.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords