Keywords: Neurodegeneration, Diabetes, small vessel diseases (CSVD)、cognition、freesurfer
The objective of this study was to explore the changes of cortical thickness in patients with type 2 diabetes mellitus, and the correlation between the thinning cerebral regions and cerebral small vessel diseases (CSVD) burden. The thickness of the left medial orbitofrontal cortex was negatively correlated with the centrum semi-ovale enlarged perivascular space (CSO-EPVS) score and CSVD total burden score. The thickness of the left lateral occipital cortex was negatively correlated with CSO-EPVS score, basal ganglia enlarged perivascular space (BG-EPVS) score, and CSVD total burden score, and positively correlated with mini-mental state examination (MMSE) delayed memory score.
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