Abstract #1544

Detecting longitudinal alterations of cerebral white matter associated with breast cancer and chemotherapy using GQI

Wei Chuang¹, Vincent Chin-Hung Chen^2,3, Yuan-Hsiung Tsai^2,4, and Jun-Cheng Weng^1,3,5

¹Department of Medical Imaging and Radiological Sciences, and Department of Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, ²School of Medicine, Chang Gung University, Taoyuan, Taiwan, ³Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁴Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Synopsis

Keywords: Brain Connectivity, Diffusion/other diffusion imaging techniquesIn 2020, breast cancer is the most prevalent type of cancer and has the highest incident rate in women worldwide. The extensively used adjuvant chemotherapy might have detrimental effect on human brain and results in chemotherapy-related cognitive impairment (CICI) in breast cancer patients. The present study performed longitudinal design, aiming to investigate the microstructural and macroscale white matter alterations by generalized q-sampling imaging (GQI). Our results suggested that the patients had changes in local white matter integrity and network performance in DAN before treatment and frontal lobe connection after treatment.

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