Abstract #1545

Study of mouse models of lesion by using a multi technique approach.

Laura Maugeri^1,2, Charles Nicaise³, Aleksandar Jankovski^4,5, Emil Malucelli⁶, Mauro DiNuzzo^2,7, Alessia Cedola⁸, Federico Giove^2,7, and Michela Fratini^2,8

¹Institute of Nanotechnology Lecce Unit & Rome Unit, CNR, LECCE, Italy, ²Laboratory of Neurophysics and Neuroimaging (NaN), IRCCS Santa Lucia Foundation, Rome, Italy, ³URPhyM – NARILIS, Université de Namur, Namur, Belgium, ⁴Institute of NeuroScience (IoNS), NEUR division, Université catholique de Louvain (UCLouvain), Brussels, Belgium, ⁵Department of Neurosurgery, Université catholique de Louvain (UCLouvain), CHU UCL Namur, Yvoir, Belgium, ⁶Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy, ⁷Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Rome, Italy, ⁸Institute of Nanotechnology, CNR, ROME, Italy

Synopsis

Keywords: Spinal Cord, Data Processing, SPINAL CORD INJURYInnovative biomarkers as well as new modalities to integrate structural information at higher level should be tuned up in order to understand the mechanisms underlying the pathology evolution. Here, we show some results obtained by integrating morphological information from X-ray phase contrast microtomography with histology combined with immunohistochemistry. Thanks to this approach, we demonstrated the possibility to use the cell number variation as a biomarker for pathological conditions.

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