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Abstract #1547

Contribution of diffusion MRI to neuropathic pain in the SNL rat model: correlation between gliosis and diffusion parameters

Sang-Jin Im1, Seokha Jin1, and HyungJoon Cho1
1Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea, Republic of

Synopsis

Keywords: Spinal Cord, Diffusion Tensor ImagingIn this study, magnetic resonance imaging is used for anatomical and pathological studies of the spinal cord, investigating the mechanisms of neuralgia through diffusion magnetic resonance imaging techniques. However, analysis of ganglion changes in the spinal cord in multi-shell diffuse-weighted MRI signals remains challenging due to the ambiguous relationship between sympathetic and MRI signals. To study these relationships, we construct a neuropathic pain model using rats by performing in ex-vivo MRI experiments and neuropathic cell staining to provide insight into the treatment of neuropathic pain.

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