Abstract #1548

Anisotropic and Isotropic Kurtosis Estimation of Spinal Cord Microstructure in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Masaaki Hori^1,2, Akifumi Hagiwara², Kazumasa Yokoyama³, Issei Fukunaga⁴, Katsuhiro Sano², Koji Kamagata², Katsutoshi Murata⁵, Shohei Fujita^2,6, Christina Andica⁷, Akihiko Wada², Kouhei Kamiya^1,2, Julien Cohen-Adad⁸, and Shigeki Aoki^2,7

¹Toho University Omori Medical Center, Tokyo, Japan, ²Radiology, Faculty of Medicine, Juntendo University, Tokyo, Japan, ³Neurology, Faculty of Medicine, Juntendo University, Tokyo, Japan, ⁴Radiological Technology, Faculty of Health Science, Juntendo University, Tokyo, Japan, ⁵Siemens Japan K.K., Tokyo, Japan, ⁶Radiology, The University of Tokyo, Tokyo, Japan, ⁷Faculty of Health Data Science, Juntendo University, Chiba, Japan, ⁸NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada

Synopsis

Keywords: Spinal Cord, Spinal CordWe investigated the microstructural changes in the spinal cords of patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using anisotropic kurtosis and isotropic kurtosis (K_iso) derived from 2-shell single diffusion encoding (SDE) MRI data with spherical mean techniques (SMT) and mean signal diffusion kurtosis imaging. There was a significant difference in K_iso between MS and NMOSD at the level of C4 (P=0.032, Mann-Whitney U test with Bonferroni correction). Therefore, K_iso derived from 2-shell SDE data might potentially be useful for evaluating the spinal cord microstructure in MS and NMOSD patients.

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