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Abstract #1555

Reliability of spinal cord measures based on Synthetic T1-weighted MRI derived from multi-parametric mapping (MPM)

Simon Schading1, Maryam Seif1,2, Tobias Leutritz2, Markus Hupp1, Armin Curt1, Nikolaus Weiskopf2,3, and Patrick Freund1,2,4
1Spinal Cord Injury Center, Balgrist University Hospital, Zürich, Switzerland, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Felix Bloch Institute for Solid State Physics, Leipzig University, Leipzig, Germany, 4Wellcome Trust Centre for Neuroimaging, UCL Queen Square Institute of Neurology, London, United Kingdom

Synopsis

Keywords: Spinal Cord, Quantitative Imaging

MRI acquisition time is a main factor for patient's comfort and motion artifacts. To avoid additional time consuming T1-w MPRAGE imaging for measuring spinal cord atrophy, when quantitative multi-parameter maps (MPM) are available, we reconstructed and validated a synthetic T1-w (synT1-w) based on MPMs. Test-retest repeatability was assessed and synT1-w images were compared with T1-w MPRAGE in a longitudinal study following spinal cord injury. Measures derived from synT1-w demonstrated high intra- and inter-site repeatability with only small difference when compared to MPRAGE. The estimated effects of spinal cord atrophy agreed with those obtained from MPRAGE.

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