Abstract #1577

7T metabolic MRI in three types of diffuse glioma

Sarah M Jacobs¹, Evita C Wiegers¹, Zahra Shams¹, Jannie P Wijnen¹, Peter W.A. Willems², Pierre A Robe², Angelika Mühlebner^3,4, Wim Van Hecke³, Maeike Zijlmans^2,5, Dennis WJ Klomp¹, and Anja G van der Kolk^1,6

¹Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands, ²UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands, ³Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Pathology, Amsterdam University Medical Center, location AMC, Amsterdam, Netherlands, ⁵Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands, ⁶Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands

Synopsis

Keywords: Tumors, Tissue CharacterizationWe combined metabolic magnetic resonance imaging (MRI) sequences at 7 Tesla (7T) to characterize glioma tissue and discover metabolic MRI profiles that could help delineate the extent of disease spread and determine molecular tumor subtypes preoperatively. Here we show the first preliminary results of three different diffuse glioma subtypes imaged with ¹H MR spectroscopy (MRS), ³¹P 3D chemical shift imaging (CSI), glutamate chemical exchange saturation transfer (GluCEST) and quantitative susceptibility mapping (QSM).

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