Abstract #1580

Arterial spin labeling MRI can predict prognosis of patients with newly-diagnosed primary CNS lymphoma

Hao Wu¹, Zhenwei Yao¹, Bobin Chen², Hui Kang², Huaping Sun¹, Yan Ren¹, Shuguang Chu³, Na Lu¹, Xianjing Zhao¹, Jie Wu¹, Yan Ma², Yan Yuan², Tianling Ding², Zhiguang Lin², Jingjing Ma², Qing Li², Xianjin Zhou⁴, Yiqian Zhu⁵, Tianyong Xu⁶, and Yong Zhang⁶

¹Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China, ²Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China, ³Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China, ⁴Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan University, Shanghai, China, ⁵Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China, ⁶GE Healthcare, Shanghai, China

Synopsis

Keywords: Tumors, Arterial spin labelling, primary CNS lymphoma, cerebral blood flow, prognostic factorPCNSL is a heterogeneous and aggressive non-Hodgkin lymphoma with poor prognosis. The present study revealed that 3D-ASL MR perfusion imaging-derived rCBF values pre- and posttreatment can be used as predictors for patients with newly diagnosed PCNSL. Furthermore, this is the first study identifying rCBFmean as an independent predictor for overall survival. Different from the traditional prognostic scoring system, the study provided a noninvasive MRI technique that requires no contrast agent or radiation exposure. Inclusion of the 3D-ASL sequence in routine MRI protocols is highly recommended to help to optimize individualized treatment and improve prognosis.

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