Abstract #1581

Spatially Explicit Analysis of Tumor Hypoxia Heterogeneity from IVIM MRI Predicted Survival of Higher-Grade Glioma

Xiaoqing Wang¹, Mengqiu Cao¹, Yang Song², Guang Yang³, and Yan Zhou¹

¹Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, ²MR Scientific Marketing, Siemens Healthineers Ltd. Shanghai, China, Shanghai, China, ³Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China

Synopsis

Keywords: Tumors, Brain, Diffusion weighted MRIThis study investigated the feasibility of spatially explicit analysis based on IVIM MRI to identify hypoxia-related habitats with higher-grade glioma, and to predict progress-free survival in patients. The results showed that spatial explicit analysis on IVIM MRI could be an appropriate method for distinguishing different hypoxic subregions in glioma. In addition, the volume percentage of less hypoxic habitats can effectively predict progress-free survival in higher-grade glioma.

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