Abstract #1610

Clinical application of MULTIPLEX as a rapid multi-parametric brain imaging method in early Parkinson’s disease

Tong Fu¹, Rongrong Pan², Youyong Tian², Qing Gao², Xinying Wu ¹, Lindong Liu¹, Hai Lin³, and Yongming Dai³

¹Department of Radiology, Nanjing first hospital，Nanjing Medical University, Nanjing, China, ²Department of Neurology, Nanjing first hospital，Nanjing Medical University, Nanjing, China, ³Central Research Institute, United Imaging Healthcare, Shanghai, China

Synopsis

Keywords: Quantitative Imaging, Multi-ContrastQuantitative MRI can measure a variety of physiological tissue parameters, such as longitudinal T1 value, transverse T2 value and proton density, iron content and fat content. We tried to apply a multi-parametric MR imaging technique of MULTIPLEX that provides the maps of T1, T2*, proton density and quantitative susceptibility mapping into the diagnosis of early Parkinson’s disease (PD). We found that MULTIPLEX could provide comprehensive and quantitative assessment of Parkinson’s disease-related subcortical nucleus and dopaminergic midbrain regions captured in multiple MR imaging parameters, which might assist in the diagnosis and better understanding of early Parkinson’s disease under tight clinical time-constraints.

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