Abstract #1622

Measurement of NAD+ T1 relaxation time at 7T in the human brain using saturation recovery downfield MRS

Neil Wilson¹, Sophia Swago², Mark Elliott¹, Ravi Prakash Reddy Nanga¹, Ravinder Reddy¹, and Walter Witschey¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Bioengineering, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Quantitative Imaging, SpectroscopyHere we present a method based on spectrally selective saturation recovery 1H spectroscopy to measure the apparent T1 values of NAD+ in the downfield at 7T for the first time. With spectrally selective saturation and excitation, NAD+ exhibits enhanced T1 recovery do to cross relaxation with water, and we report values in three subjects between 200 and 300 ms. Measuring apparent T1 is crucial as a correction factor for quantitative spectroscopy of NAD+.

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